Prophylactic Antiparasitic Transgenesis for Human Parasitic Disease?

Human Parasites and Parasitic Disease

Transgenesis for pig models

Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expres...

Isoenzymes in parasitic disease.

Successful transgenesis of the parasitic nematode Strongyloides stercoralis requires endogenous non-coding control elements.

Critical investigations into the cellular and molecular biology of parasitic nematodes have been hindered by a lack of modern molecular genetic techniques for these organisms. One such technique is transgenesis. To our knowledge, the findings reported here demonstrate the first heritable DNA transformation and transgene expression in the intestinal parasite Strongyloides stercoralis. When micro...

Diagnosis of parasitic disease.

Diagnosis of parasitic diseases requires highly sensitive and specific tests. In many cases the identification of parasites concerns their epidemiology and it is important to distinguish between species and subspecies. Conventional techniques including serology and microscopy do not always meet these requirements. The principle of nucleic acid probes is that a specific sequence of the parasite'...